Responded to @oivaeskola:
@oivaeskola Yes, since HomeAssistant supports running the full “operating system” inside Virtualbox (same as Hass.io) so you can install all the add-ons (basically Docker containers with some meta data) through the built-in tooling. You will need to forward the serial port to Virtualbox machine for the zigbee dongle, but everything else should be possible to configure from the UI.